HORDB

ID: hor004201
Uniprot ID: P20757
Protein name: Angiotensin-1
Gene name: AGT
Organism: Ovis aries (Sheep)
Family: Serpin family
Source: animal
Expression: Expressed by the liver and secreted in plasma.
Disease: NA
Comments: NA
Taxonomy: Ovis (genus), Caprinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0004867 serine-type endopeptidase inhibitor activity
GO BP: GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin; GO:0010718 positive regulation of epithelial to mesenchymal transition; GO:0042310 vasoconstriction; GO:0097746 blood vessel diameter maintenance; GO:1901394 positive regulation of transforming growth factor beta1 activation
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: DRVYIHPFHL
Length: 10
Propeptide: MAPAGLSLGATILCLLAWAGLAAGDRVYIHPFHLLVHSKSNCDQLEKPSVETPADPTLTPVPIQTKSSPVDEEALWEQLVRATEKLEAEDRLRASEVGLLLNFMGFHVYKTLSETWSVASGLVFSPVALFSTLTSFYTGALDPTASRLQAFLGVPGEGQGCTSRLDGRKVLSSLQTIQGLLVAPGGASSQARLLLSTVVGLFTAPGLHLKQPFVQGLSSFAPITLPRSLDLSTDPNLAAEKINRFMHSATGWNMGRPLAAASPDSTLLFNAYVHFQGKMKGFSLLPGLTEFWVDNTTSVPVPMLSGSGTFHYWSDNQNHLSMTRVPLSANGYLLLIQPHHTLDLRKVEALIFQHNFLTRMKNLSPRAIHLTVPQLTLKASYDLQDLLAQAKLPTLLGAEANLGKISDANLRVGKVLNSVLFELKADGEQAPESVPQPAGPEALEVTLNSPFLLAVLERSSGALHFLGRVSRPLSAE
Signal peptide: MAPAGLSLGATILCLLAWAGLAAG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
Mechanism: NA
Cross BBB: YES
Target: AGTR2
Target Unid: Q28929
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: 1 hours; /3600 seconds ( PubMed ID: 22186872 )

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004201_AF2.pdb

hor004201_ESM.pdb

Mass:	145721	Formula:	C62H89N17O14
Absent amino acids:	ACEGKMNQSTW	Common amino acids:	H
pI:	7.71	Basic residues:	3
Polar residues:	1	Hydrophobic residues:	4
Hydrophobicity:	-20	Boman Index:	-1624
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	107
Instability Index:	2264	Extinction Coefficient cystines:	1490
Absorbance 280nm:	165.56